Abstract:
Breast cancer is the leading cause of cancer worldwide. The high expenses associated with
chemotherapy as well as its side effects make the management of breast cancer a daunting
challenge. Recent investigations into cancer treatment have revealed that plant extract
demonstrate potential anti-cancer properties through different pathways. In these studies roots,
fruits and leaves of six selected medicinal plants were used for in vitro models to evaluate
phytochemical components, antioxidant activities and potential cytotoxicity on CMF-7 breast
cancer cells. The antioxidant activities were evaluated by using DPPH and reducing power
assays. The results of the antioxidant study revealed that the selected plants were found to be
effective in scavenging 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical and reducing Fe+3 to
Fe+2.. The antioxidant activities when compared among roots, leaves and fruits of the plants the
potency of these extracts were found to be in the order of ascorbic acid > Kalanchoe petitiana >
Curcuma longa > Zingiber officinale >Embelia Schimperi > Brucea Antidysenterica ≥ Withania
Somnifera. Exceptionally, Kalanchoe petitiana ethanol extract possessed all the tested secondary
metabolites such alkaloids, terpenoids, saponin, phenols, tannins, flavonoids, and trepenoids.
Finally, the cell viability results indicate that Curcuma longa/Turmeric (Erid), Zingiber officinale
/Ginger (Zenjib), Withania somnifera (Gizawa) and Kalanchoe petitiana (Indahula) were the
most effective plants against CMF-7 breast cancer. Therefore, the present findings strengthen the
potential of the selected plants as a resource for the discovery of novel breast anticancer and
antioxidant agents.
