Abstract:
Background: Post-streptococcal acute glomerulonephritis is a nonsuppurative Group A
streptococcal complication. Globally, I t causes about 404,000 cases in children. In Mekele,26.9%
of children with post-streptococcal acute glomerulonephritis had poor treatment outcomes. Most
studies in Ethiopia were on outcomes and little was on associated factors of treatment outcome
particularly in the study area.
Objective: To assess the treatment outcome of post-streptococcal acute glomerulonephritis and
its associated factor among children of less than 15 years at a referral hospital in Amhara Northeast
Ethiopia,2022
Method: An institutional-based cross-sectional study was conducted with a sample size of 332. A
simple random sampling method was applied to select the study subject. The data was collected by
using a checklist in the medical record. The collected data were coded and entered in Epi data
version 4.6 and exported to STATA version 14.0 for analysis. The bivariable analysis was done and
all independent variables which have an association with the outcome variable at a p-value <0.25
were entered into the multivariable model. A p-value <0.05 was considered as a cut of value to
indicate statistical significance.
Results In this study a total of 322 Post- streptococcal acute glomerulonephritis children with a
response rate of 97% were included. Of these, 33.54% of them had a poor treatment outcome. Age
less than or equal to 5 years (AOR =3.2 with 95% CI (1.5-7.3), Creatinine level >1.3mg/dl
(AOR=5.5 with 95% CI (2.5-11.7), blood urea nitrogen leve≥119mg/dl (AOR=4.9 with 95% CI
(1.1- 19) and length of stay >10 days(AOR=2.6 with 95% CI (1.18 - 5.9) were statistically
significant with poor outcome of children with post-streptococcal acute glomerulonephritis.
Conclusion In this study, the overall poor treatment outcome for children with post-streptococcal
acute glomerulonephritis was higher. Age ≤ years, length of stay greater than 10 days, creatinine
≥1.3mg/dl, and blood urea nitrogen ≥119mg/dl were significantly associated factors for poor
outcomes. Therefore, children with the significant predictors need complete investigation ,frequent
follow up and management during admission to redsuce poor treatment outcome.
